第66回日本生物工学会大会

第11回生物工学アジア若手賞の受賞講演は、第66回日本生物工学会大会の2日目(2014年9月10日)に行われます。

• 日時： 2014年9月10日 15:20～15:40
• 場所： 1階　C 会場(107+108) 　
• 演題： Antibody engineering and production in bacterial hosts
• 発表者： ○Ki Jun Jeong, Yong Jae Lee, Hee Sung Kim, Seung Hoon Jang, Sung Sun Yim (Department of Chemical and Biomolecular Engineering, KAIST, South Korea)
• 座長： 横田篤

⇒受賞者（Dr. Ki Jun Jeong）紹介（英語サイト）
⇒生物工学アジア若手賞受賞者一覧はこちら

講演要旨

Today, therapeutic antibodies are the most well characterized proteins and, after the appearance of the first FDA-approved antibody 25 years ago, antibodies have become major therapeutic agents in the treatment of many human diseases, including cancer and infectious diseases. So far, a variety of strategies have been devised for engineering of these fascinating molecules to develop superior properties and functions. Recent development of biotechnology tools, particularly in regard to high-throughput screening, has made it possible to perform more intensive engineering on these substances. Based on a sound understanding and new technologies, antibodies are now being developed as more powerful drugs. In this presentation, first, Id like to introduce our recent achievements that has been made in antibody engineering. By combination of new protein display systems and FACS screening, we succeeded in the engineering of various antibodies including scFv, Fab and full-length IgG. Second, the recent strategy for the production of antibodies in bacterial host will be presented. By engineering of bacterial host (particularly secretion and folding machineries of hosts) and optimization of culture conditions, the production yield of antibodies (from small scFv to full-length IgG) could be significantly enhanced.