公益社団法人 日本生物工学会

Vol. 98, December 2004

Structure of vitamin B₁₂ (cyanocobalamin).

To increase the production of the vitamin by Propionibacterium freudenreichii, a known producer of this important vitamin in medical and food areas, more than 10 genes belonging to the hem, cob and cbi gene families involved in the vitamin B₁₂ synthetic pathway of P. freudenreichii and other bacteria were overexpressed in the bacterium, and approximately 2-fold higher productivity was attained, confirming the greater usefulness of the bacterium for the production of vitamin B₁₂ compared to chemical synthesis, which requires more than 70 complicated steps.

Related article: Piao, Y., Yamashita, M., Kawaraichi, N., Asegawa, R., Ono, H., and Murooka, Y., “Production of vitamin B₁₂ in genetically engineered Propionibacterium freundenreichii“, J. Biosci. Bioeng., vol. 98, 167-173 (2004).

⇒JBBアーカイブ：Vol.107 (2009) ～最新号
⇒JBBアーカイブ：Vol. 93（2002）～Vol. 106（2008）